The phrase "a significant breakthrough was" is correct and usable in written English.
It can be used when discussing an important development or discovery in a particular field or context.
Example: "In the field of medicine, a significant breakthrough was achieved in the treatment of cancer, leading to improved patient outcomes."
Alternatives: "an important advancement was" or "a major discovery was".
For assessing the potential of a chemical to be toxic, a significant breakthrough was the creation of cheap and short-term alternatives to the rodent bioassay, the main tool of the research on chemical carcinogens.
Recently, a significant breakthrough was made when some research groups showed that graphite could be exfoliated by non-chemical solution phase methods with solvents[11 13] or surfactants[14, 15].
R1128 also resolves the contradictions of giant panicle and lower seed setting rate in previous generations when a significant breakthrough was achieved in creating hybrid rice parents through wide crosses between subspecies.
A significant breakthrough was achieved when the study of membrane protein conformation became possible.
A significant breakthrough was achieved through filter papers for the diagnosis of diseases, genotyping and sero-surveillance.
But she believes a significant breakthrough is near.
The agent that should be considered a significant breakthrough is definitely vemurafenib, a highly specific inhibitor of the BRAF kinase that harbours the mutation V600.
An unexpected yet significant breakthrough was the discovery of a link between RNAi and transcriptional silencing in fission yeast (Volpe et al., 2002).
Marconi's most significant breakthrough was yet to come.
Though no significant breakthrough was expected out of the Singh-Sharif meeting, that fact that it was even taking place sends a positive signal to both countries, analysts said, while canceling it reverses hope of modest progress anytime soon.
A significant breakthrough discovery was unearthed by the Linus Pauling Institute and Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, United States earlier this year.
