The phrase "a significant breakdown" is correct and usable in written English.
It can be used to describe a major failure or collapse in a system, process, or relationship.
Example: "The project faced a significant breakdown in communication, leading to delays and misunderstandings among team members."
Alternatives: "a major failure" or "a critical collapse".
That the order was openly flouted suggested a significant breakdown of military discipline.
Entwistle acknowledged that there had been a "significant breakdown in communication" between Rippon and the Newsnight producer and reporter behind the investigation, Meirion Jones and Liz MacKean.
Days after David Cameron announced a campaign against councils that failed to help people wanting to adopt, research from the National Autistic Society (NAS) reveals a significant breakdown in support that can extend for years.
Girardi has juggled the veterans without a significant breakdown for months, and recognized his mistake in playing Alex Rodriguez too many games in a row after he returned in May.
Brad Hintz, a securities analyst at Sanford C. Bernstein, summed it up this way, "Merrill's $4.5 billion write-down is significantly higher than that of its peers and represents a significant breakdown of the firm's risk management process".
A cut in the number of Crown Prosecution Service lawyers of almost 25%, coupled with rising administrative errors in the courts, has triggered fears that budget reductions are causing a significant breakdown in the criminal justice system.
"John Lewis is a good antidote to how much of our economy is externally controlled and driven by the obsessive short-termism that creates a significant financial breakdown every generation".
"Something that all of us, all five doctors, thought was remarkable was that his skin was in very good, in fact excellent, condition, considering he had been bedridden for over a year," Sammarco said: No bed sores, no significant breakdown of the skin, no pressure sores.
It appears that even in patients at a late stage of empyema, IPSTK resulted in significant breakdown of loculations.
CD2Br2 additions revealed that CH2Br2 was subject to significant breakdown in cultures of both Thalassiosira sp. and a bacterial isolate with apparent loss rate constants ranging from 0.21 to 0.78 day− 1.
