The phrase "a significant bottleneck in" is correct and usable in written English.
It can be used to describe a major obstacle or hindrance in a process, system, or project.
Example: "The outdated software has created a significant bottleneck in our production line, slowing down overall efficiency."
Alternatives: "a major obstacle in" or "a critical hindrance in".
A significant bottleneck in using SHAPE is the complex and time-consuming data processing that is required.
Maryland consumers continued to encounter "a significant bottleneck" in creating accounts that are the first step toward shopping on the state's exchange, according to Joshua Sharfstein, Maryland's health secretary.
Gholam-Abbas Nazri, a researcher at the GM Research & Development Center in Michigan, calls this research "interesting and important," and says this addresses a significant bottleneck in the development of this technology: the need find an efficient catalyst.
A significant bottleneck in the verification process of such designs is that not enough time is usually given to the final coverage phase, which makes computing cycles very precious.
As any well-designed information security application uses a very large quantity of good pseudorandom numbers, inefficient generation of these numbers can be a significant bottleneck in various situations.
A significant bottleneck in oncology drug development is the recruitment of patients for clinical trials.
However, a significant bottleneck remains in establishing correct sidechain assignments at sufficient completeness levels to drive the automated assignment of long-range NOEs20.
"You have a significant bottleneck, the worst bottleneck in the North American freeway system," said Michigan Lt. Gov. Brian Calley, who along with a fellow Republican, Gov. Rick Snyder, has aligned himself with labor and the Big Three in favor of a second bridge over the Detroit River.
This process results in a significant bottleneck that is costly both in terms of the resources required and the likelihood that the system is not capturing all of the knowledge that is produced [ 7].
Although the binding characteristics of nonspecific interactions is much different than that for a specific binding event, nonspecific interactions and binding still poses a significant bottleneck for limit-of-detection in biosensors.
Populations that have experienced a significant bottleneck are expected to suffer a reduction in population genetic diversity.
