The phrase "a significant block in" is correct and usable in written English.
It can be used to describe an important obstacle or hindrance in a particular context, such as a process, project, or situation.
Example: "The lack of funding has become a significant block in the development of the new software."
Alternatives: "a major obstacle in" or "a considerable barrier to".
In these studies we observed a significant block in cell invasion in the presence of Fsn0503, of up to 37% at 500 nmol/L (Fig. 2A).
Tregs from GITR−/− mice did not show a significant block in trafficking when transferred into DTA-1 treated animals, compared to IgG controls, demonstrating a requirement for direct GITR ligation on Tregs themselves (Figure 4B).
Only the combination of AEE788 with dovitinib caused a significant block in the PI3K/Akt/mTOR pathway and resulted in strong anti-tumor activity.
We did not observe a significant change in frequency in the control mixes (labeled versus unlabeled), nor did we observe a significant block effect in either experimental or control mix.
From that political base, Ms Gordillo controls a significant block of deputies in the lower house of the federal Congress, as well as two senators.
That forecast has the ring of an athlete's pregame boast, but, if a free vote is held, political analysts expect Khan to emerge with a significant block of seats in parliament, and it is possible that he could end up as President or Prime Minister.
Even additions even of 1 mM OAA, however, resulted in a significant block of ICl consistent with an apparent Ki near 0.1 mM and well within the dynamic concentration range for OAA in vivo [ 30].
During the course of these studies, we noticed that in most cell lines including U2OS cancer cells and non-cancer cells such as retinal pigment epithelial cells CHD4 depletion resulted in a significant block or delay at the G1/S cell-cycle transition.
(2) Acute administration of clozapine/cocaine (20 and 10 mg/kg ip, respectively; n=6) produced a significant block of the cocaine-induced increase in DA (P<.001) and 5-HT release (P<.001).
Importantly, there was a significant block of invasion into the brain in the treatment group, which was most pronounced proximal to the injection site, where tumors showed a demarcated border (Fig. 4d, e).
This approach is based on the multiresolution fusion principles to embed the grayscale logo in perceptually significant blocks in wavelet subband decompositions of the host image.
