Although NIH now plans to enroll nearly 10,000 people in each arm of the Liberian trial, current infection rates mean it will take about 6 months to reach a statistically significant answer if the vaccine protects 50% of those who get it, says Ripley Ballou, who heads GSK's Ebola vaccine project.
Perhaps additional follow-up in MSLT 1 will yield a statistically significant answer in the fourth interim or final analyses yet to come, but since the procedure is essential to accurate staging, decreases disease recurrence, and can be done with minimal morbidity, that particular question is essentially moot.
An inappropriate or invalid research method will either not generate an answer to the question, or will not result in a meaningful or significant answer to the question.
One significant answer comes from a legislative milestone: the Adoption Assistance and Child Welfare Act of 1980, legislation that helped lower-income families to adopt children out of the foster care system and to address the special and ongoing needs those children frequently carried.
Therefore, our results give a significant partial answer to the open question.
Kasparov found no significant answer to Karpov's new method.
The most significant answer, I'd suggest, is the growing importance of monopoly rents: profits that don't represent returns on investment, but instead reflect the value of market dominance.
Only 20% of the patients wanted the doctor to introduce them to a support network whereas 10% answered with 'do not know' and a significant 70% answered that it was not important for them to be part of a support network.
This may be assessed from table 5, which shows the estimated probability of each answer in the intervention groups for those outcomes showing a significant difference in answer profiles between the two groups.
