The phrase "a significant and substantive" is correct and usable in written English.
It can be used to describe something that is both important and meaningful, often in contexts such as research, discussions, or evaluations.
Example: "The study provided a significant and substantive contribution to our understanding of climate change."
Alternatives: "a meaningful and important" or "a considerable and essential".
"What the city is asking for raises significant and substantive civil liberty and constitutional questions," said Norman Siegel, the organization's executive director.
We will make changes, we'll make significant and substantive changes to the legislation which at the moment is – if you like – it's suspended in the House of Commons, in order to make sure that those who perhaps develop some very serious and legitimate doubts about some of the details of the plans feel that it's now on the right track again and then we can move forward together".
The use of intraoral photographs and video images was not common, although there was statistically significant and substantive diversity evident.
The monthly practice volume of root canals and dental extractions - regardless of whether the DPBRN practitioner-investigator performed the procedure or whether it was referred to another dentist - also showed statistically significant and substantive diversity among DPBRN practices [Additional file 1-Table S1].
We can conclude that our objective was indeed met because we were able to document statistically significant and substantive differences in key characteristics within and between DPBRN regions, based on responses to the DPBRN Enrollment Questionnaire from dentists who participated in DPBRN's first network-wide study.
We determined whether or not we met this objective by testing the hypothesis that there are statistically significant and substantive differences in key characteristics across DPBRN regions, based on responses to the DPBRN Enrollment Questionnaire from dentists who participated in DPBRN's first network-wide study.
We do not observe a significant or substantive decline in work inside the family at the minimum age in any of the countries.
