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The phrase "a significant and persistent" is correct and usable in written English.
It can be used to describe something that is both important and enduring over time, often in contexts such as research, analysis, or discussions about issues.
Example: "The study revealed a significant and persistent increase in temperature over the last century."
Alternatives: "a notable and ongoing" or "a considerable and lasting".
Exact(30)
IT'S one of the biggest what-ifs in the markets: What if oil prices stage a significant and persistent retreat?
An authorisation may be made for up to six months where there are reasonable grounds for believing that members of the public have been intimidated, harassed, alarmed or distressed as a result of the presence or behaviour of groups of two or persons in public places in that area, and that anti-social behaviour is a significant and persistent problem in the area.
Although dysphagia usually improves over 6 months, it remains a significant and persistent problem for some patients.
"We have also found a significant and persistent link between integrity and market returns," the company says.
Although the results show a significant and persistent poor matching quality for foreign-educated immigrants, their relative underutilization cost is negligible.
We find a significant and persistent increase in infant mortality rates and a more modest decrease in birth rates as a result of state centralization.
Similar(29)
These animals also showed a statistically significant and persistent increase (normalization) in PWT from baseline for the next 15 days after IT treatment (figure 7A B).
The extended simulation methodology was associated with a modest but significant and persistent positive impact on students' prescribing skills that was additional to the benefit directly consequent on participation in the associated prescribing workshops already demonstrated in a (non-randomised) controlled trial by Coombes and colleagues [ 26].
"I reached this decision as a result of the significant and persistent workload associated with my service on the board, which I did not anticipate when I joined the board," Mr. Rohmer said in a statement issued by Hollinger.
Following single as well as multiple injections, TG1050 can educate functional T cells in a HBV chronic environment and display significant and persistent antiviral activity, in particular an impact on the level of HBsAg.
According to the authors, "only a few announcements the nonfarm payroll numbers, the GDP advance release and a private sector manufacturing report have significant and persistent effects".
More suggestions(15)
a significant and chronic
a significant and steady
a prominent and persistent
a major and persistent
a large and persistent
a significant and ongoing
a remarkable and persistent
a vital and persistent
a significant and sustained
a significant and lasting
a significant and enduring
a puzzling and persistent
a significant and influential
a systemic and persistent
a significant and unlikely
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com