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The phrase "a significant and enduring" is correct and usable in written English.
It can be used to describe something that has a considerable impact and lasts over time, often in contexts like research, literature, or discussions about influence.
Example: "The study revealed a significant and enduring effect of climate change on biodiversity."
Alternatives: "a substantial and lasting" or "a meaningful and persistent".
Exact(10)
However, it said the virus still posed a "significant and enduring" threat.
We hypothesized that, compared with individuals with persistent prediabetes or diabetes, those reaching NGR in the DPP would have a significant and enduring decreased estimated risk of CVD over the period of observation in DPPOS.
For such a significant and enduring land use change policy it is prudent to assess both the economic and environmental potential under climate change.
Still, for Mr. Key and others, the primary challenge remains linked tightly to Mr. Jackson: how do you build a significant and enduring economic sector from a local business dominated by one man?
The design of efficient visible-light-driven photocatalysts that use low-cost and earth-abundant materials with easy recyclability is a significant and enduring theme for solar energy conversion with practical applications.
They have been only slightly more impressed when President Obama sought to create what he calls a "significant and enduring" level of military and development aid, so the two countries do not lurch from crisis to crisis.
Similar(50)
Rosen argues that renewed investment in New York's garment industry could drive more significant and enduring growth than a quick rise in rents.
Its principle are significant and enduring".
Increased likelihood of transformation that's both significant and enduring.
The trustee committee's report emphasizes, and I agree wholeheartedly, that our most significant and enduring challenges pertain to enhancing the diversity and inclusivity of our community.
I have read it four times straight through and more in part, and it has increased in power each time, strengthening my belief that Barry will emerge as one of the most significant and enduring of contemporary writers.
More suggestions(16)
a significant and undergoing
a tangible and enduring
a vast and enduring
a substantial and enduring
a remarkable and enduring
a major and enduring
a huge and enduring
a significant and long term
a significant and permanent
a significant and protracted
a significant and long
a significant and long lasting
a significant and persistent
a significant and durable
a strong and enduring
a deep and enduring
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com