The phrase "a significant and durable" is correct and usable in written English.
It can be used to describe something that has both importance and lasting quality or strength.
Example: "The research findings indicate that the changes implemented have led to a significant and durable improvement in student performance."
Alternatives: "a meaningful and lasting" or "an important and enduring".
After cross-over of 11/15 patients to EP boosting, there is a significant and durable increase to the end of the study but we can no longer assess the impact of the individual delivery modalities.
An intensive intervention strategy delivered at the clinic level is associated with a significant and durable improvement in major CVD risk factors and HbA1c, well beyond that achieved with the usual practices.
In addition, a 24-week randomized controlled trial with a 52-week extension evaluating saxagliptin 5 or 10 mg plus metformin IR as initial combination therapy in treatment-naive patients with type 2 diabetes demonstrated a significant and durable improvement in glycemic control with combination therapy versus either monotherapy [ 18, 19].
A large multicenter trial in 108 ICUs in Michigan saw a significant and durable decrease in the mean rate of catheter-related bloodstream infections with maximum sterile barrier precautions during insertion of central venous catheters and removal of unnecessary catheters [ 21].
MRgFUS treatment results in an immediate, significant, and durable reduction of tremor.
Fact is, it's inherently quite difficult to come up with an innovation that improves health in a significant, measurable, and durable fashion, and it's extraordinarily difficult to improve health to the degree that you actually reduce costs.
The combination of another Hsp90 inhibitor, 17-AAG, and bortezomib has already been investigated in a Phase II study, and has demonstrated significant and durable responses with acceptable toxicity in patients with relapsed and refractory MM.
From the 1960s until the 1980s, empirical questions concerning civic education were relatively neglected, mainly because of a prevailing assumption that intentional programs would not have significant and durable effects, given the more powerful influences of social class and ideology (Cook, 1985).
Equally important, the series is a crowbar meant to pry open a rigid canon and admit outliers whose work, however obscure, has proved significant and durable.
Something significant and durable also happened to the supply side of the economy.
These properties have translated into significant and durable clinical responses, particularly in advanced melanoma.
