Sentence examples for a significant and difficult from inspiring English sources

This will be a "significant and difficult burden, reliant on information from others", the Chartered Institute of Taxation tells the MPs.

Acinetobacter baumannii remains a significant and difficult-to-treat pathogen that causes a range of interactions with the human host from asymptomatic colonization and carriage in the intestinal tract, respiratory tract and skin to invasive infection, such as septicemia, that can result in death.

In hindsight, we have to admit that we were quite slow in appreciating that Cryptosporidium infection in a renal transplant patient is a major, significant and difficult to treat, complication, rather than a temporary episode of diarrhoea with an unusual pathogen.

Another change to the benefits system will force businesses to report their employees' pay each time they are paid, a move described by the Chartered Institute of Taxation as an extra "significant and difficult burden".

The contextual cognitive model of coping, views coping as a manner of thinking, feeling and behaving that arises in a situation that an individual appraises as significant and difficult [ 22].

With the demise of the car manufacturing industry, the retraining challenge for its workers is significant and difficult.

Yet she conceded that News Corp. was "asking itself some very significant and difficult questions about how some behaviors fell so far short of its values".

Income is indeed depressed, much to the benefit of employers, but the other side of the problem is more significant and difficult to address.

These variations are significant and difficult to estimate (Cuddy et al. 1993; Paul 2001; Kumar 2011; Seth et al. 2013).

The disocclusion problem is considered to be the most significant and difficult one of the DIBR algorithm.

This counterintuitive effect shows that the full impact of information technology on power markets can be significant and difficult to anticipate.