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The phrase "a significant amount of missing data" is correct and usable in written English.
It can be used in contexts where you are discussing data analysis, research findings, or any situation where data is incomplete.
Example: "The results of the study were inconclusive due to a significant amount of missing data that affected the overall analysis."
Alternatives: "a considerable quantity of missing data" or "a large volume of missing data".
Exact(17)
"As the published paper indicates, there is a significant amount of missing data, and drop-out rates are quite high.
Because the considered genes are not universally distributed, there was a significant amount of missing data in each alignment.
However, there was a significant amount of missing data on HIV status, with 19.8% of cases having unknown status.
When there is a significant amount of missing data it is highly desirable to check the sensitivity of the results by using more than one statistical method.
Estimated dates for symptom duration were preferred for patient delays, but exact dates were preferred for primary care delays; however there was a significant amount of missing data.
Data on aspirin given within 48 hours was collected only from July 2005, resulting in a significant amount of missing data for that year.
Similar(43)
The significant amount of missing data creates a major challenge (for this task).
In this study, the influence of the global structural support provided by the social network could not be satisfactorily interpreted because of the significant amount of missing data.
It is difficult to determine whether self-reported ethnicity may explain these effects due to the significant amount of missing data on this variable.
The significant amount of missing data for some sub-items limits the generalizability of our findings, yet this is quite normal in clinical data sets where it is often neither necessary nor practical to apply all available test procedures.
Furthermore some birth cohorts have a substantial amount of missing data [15].
More suggestions(14)
a significant quantity of missing data
a substantial amount of missing data
a trivial amount of missing data
a significant amount of missing responses
a considerable amount of missing data
a minimum amount of missing data
a minimal amount of missing data
a small amount of missing data
a sizable amount of missing data
a large amount of missing data
a significant number of missing data
a low amount of missing data
a modest amount of missing data
a significant proportion of missing data
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com