The phrase "a significant alteration in" is correct and usable in written English.
You can use it when discussing changes or modifications that have considerable impact or importance in a particular context.
Example: "The study revealed a significant alteration in the participants' behavior after the intervention."
Alternatives: "a major change in" or "a substantial modification to".
Adaptive response to altered environmental conditions may include a significant alteration in the gene expression of the membrane transporters that are involved in the intake or efflux of various metabolites.
Elongation stage (6 DPA) fibers from Li 1 demonstrated a significant alteration in transcript profiles, with 1,398 target sequences showing altered expression in the mutant.
Thus our results indicate a relevant mechanism for the observed increased macroscopic deformability in rickets, via a significant alteration in the mineral particle alignment, which is mediated by an altered spatial distribution of muscle forces.
Using western blotting we found that ZOL did not cause a significant alteration in the total cellular levels of pSmad2L, suggesting that ZOL alters cellular localization of pSmad2L in MDA-MB-231, but not the total quantity.
A significant alteration in the texture and morphology was also observed for the modified CN samples.
Direct compression did not induce a significant alteration in the starch-hydrolysing activity.
A significant alteration in the texture, morphology, and crystalline was also observed for the thiophene-modified CN samples.
Moreover, serum alkaline phosphatase and aspartate aminotransferase activities showed a significant alteration in MC-LR-treated animals.
In parallel, we employed Polyphen2 analysis21 to identify genes that contain amino acid substitutions that are predicted to cause a significant alteration in function and screened for genes that exhibited evidence for positive selection.
These defects were not associated with a significant alteration in regulatory gene expression, but rather with a defective ectodermal epithelium and an abnormal disintegration of the cloacal membrane.
