While sequence alignment works best for closely-related homologous proteins, i.e. proteins sharing at least 40% of their amino acid residues, structure alignment produces a significant alignment even between highly diverged homologous proteins [1].
The protein space can be visualized as a graph-like structure, where nodes represent proteins and a significant alignment is saved as an edge between two nodes.
A study led by Oxford Professor Luciano Floridi found significant alignment between many of the existing declarations, despite varying terminologies.
Interestingly, we observed significant alignment between the various activities not taken into consideration by the mid-level policymakers, and the contextual needs called forth by the front-line providers (e.g., involving potential users in the change process, improving readiness).
Blast analysis (http://blast.ncbi.nlm.nih.gov/Blast.cgi) [ 48, 49] revealed significant alignment between the nucleotidyl transferase (AIS04894.1), which was found to be over-expressed in the macrophage model (but not significantly modulated (p > 0.05) in the BALF model) and UTP-glucose-1-phosphate uridylyltransferase (GalU) (query cover 100%% and Evalue = 0.0).
BLAST [ 1, 2] is a popular and effective tool for finding significant alignments between a biological query sequence and a database of subject sequences.
Significant alignments between structurally similar proteins will usually have high core compactness which reflects the quality of the alignment.
The search detected significant alignments between the B510 genome and 43 regions of pRhico, 23 of which were mapped on pAB510f.
BLAST search of the putative "anticodon arm" returned one significant alignment with a region located between the genes ND3 and ND5 and designated as "Non-translated intergenic spacer" of Steganacarus magnus.
Using MegaBLAST with parameters of wordsize (W) = 16 and expectation (E) = 1 × 10-10 identified significant alignments with between 7% (At_TA) and 45% (Zm_TA) of the all TIGR rice loci (TRL) (see Materials and Methods for database abbreviations).
Such searches may generate significant alignment scores between unigenes either because the transcribed genes are truly homologous or because a repetitive element occurs in both transcripts.
