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In a previous work we designed a mimetic peptide possessing a significant aggregation modulating effect by means of a molecular modeling study, using a pentameric model as a molecular target.
It is evident that a significant aggregation of AgNPs takes place during particle grafting.
Rather large objects observed on AFM images show that a significant aggregation of deposited AgNPs takes place during the grafting procedure.
As enhanced concentration of α-synuclein can be a significant aggregation prone factor, promoting its self-assembly into toxic amyloid oligomeric species and amyloid fibrils, the autoimmunity can have a potential protective power, reducing its concentration in the body fluids.
However, the doses used are unlikely to provoke a significant aggregation effect [ 8].
Moreover, a significant aggregation of TF protein was observed in the cytoplasm and, especially, in the perinuclear regions of p3R-expressing cells.
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We also found a significant aggregation-state dependent Aβ1 42 effect on morphology and NG2 expression/shedding of cultured primary human NG2+HOPC.
In the later case, the presence of a nucleation barrier suppressed the onset of any significant aggregation for at least several hours, i.e. long after the completion of our SLS measurements.
Transmission electron microscopy (TEM) micrographs showed that particles are spherical, uniformly distributed without any significant aggregation (Figure 2b,c,d).
This resulted in a monodisperse solution without significant aggregation, but the particles did not partition into the holes of holey carbon films for cryo-EM.
These figures should be regarded as a conservative estimate due to significant aggregation, and are therefore not used to interpret reaction rates.
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