Sentence examples for a significant aggravation from inspiring English sources
Therefore, symptomatic pain relief is essential because pain is one of the most disabling symptoms and can thus cause a significant aggravation of joint dysfunction [ 4].
The presence of EV on endoscopy before B-RTO as a significant aggravation factor for EV after B-RTO has occasionally been reported [ 9, 11].
Most of the preclinical studies, together with some small scale clinical studies, have shown that hyperlipidaemia per se, but not the development of atherosclerosis, leads to a significant aggravation of myocardial I/R injury and to attenuation of the cardioprotective effect of both early and late preconditioning and postconditioning [reviewed in ref. (96, 97)].
Changes in inflammation, bronchiolar injury, as well as hyaline membrane, did not appear to cause any significant aggravation or had minimal contribution to total lung injury score after hyperinflation.
Higher T-bil values before B-RTO were associated with significant aggravation of EV after B-RTO, with a cutoff value of 1.6 mg/dL.
Higher HVPG values before B-RTO were also associated with significant aggravation of EV after B-RTO, with a cutoff value of 13 mmHg.
To begin with, if the federal government has conceded that vaccines can cause "significant aggravation" to the (even preexisting) autism symptoms of even just one child, shouldn't the public be notified?
Our study, showing no clinically significant aggravation of renal function, suggests that olmesartan or candesartan monotherapy may be safely used for patients with hypertension.
Although actual administration of doxifluridine was increased without significant aggravation of toxicity except neutropenia, there was no difference in survival outcomes between patients enroled before and after the introduction of a protocol amendment to increase daily dose of doxifluridine.
The median times to aggravation of EV after B-RTO were 3.8 months in group A, 5.1 in group B, and 21 in group C. A significant difference in aggravation time was found between groups A and C (P = 0.001) and groups B and C (P = 0.002) (Fig. 2B).
Follow-up study results showed complete normalization in seven patients (pre/post, 0.8 ± 0.22/1.3 ± 0.46), while three patients did not show a significant improvement (no change, n = 2; aggravation, n = 1) (Fig. 1).
