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"a significant advantage over" is correct and usable in written English.
It is usually used in the context of someone or something having an advantage over another in some way. For example: "The new technology had a significant advantage over its competitors, making it the superior choice."
Exact(60)
Lions Gate clearly gained a significant advantage over Image's drafting error.
Neither seems to have a significant advantage over the other in that contest.
Republican members of Congress said the Medicare benefit had a significant advantage over state programs.
And the knowledge gave the company a significant advantage over competitors grappling with similar problems.
That would have given its owner a significant advantage over anyone else scanning the heavens.
This gives a significant advantage over the traditional SV method in efficiency and ease of implementation.
The results indicate that such a method has a significant advantage over the previous surrogate model.
In many cases, performing general purpose computation on graphics hardware can provide a significant advantage over implementations on traditional CPUs.
On the other hand, Bolt Threads hopes to offer a significant advantage over textiles produced from fossil fuels.
M-RAM would offer a significant advantage over D-RAM, the random access memory in most personal computers.
Ms. Levine said that ABC believed Mr. Jennings had gained a significant advantage over his network competitors yesterday.
More suggestions(18)
a significant lead over
a sizable advantage over
a significant strength over
a huge advantage over
a sizeable advantage over
a vast advantage over
a notable advantage over
a large advantage over
a substantial advantage over
a prominent advantage over
a remarkable advantage over
a major advantage over
a vital advantage over
a significant trend over
a significant shift over
a 9x advantage over
a significant gain over
a significant difference over
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com