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The phrase "a shitty side effect" is correct and usable in written English, though it is informal and contains vulgar language.
You can use it when discussing negative consequences or drawbacks of a situation, particularly in casual or conversational contexts.
Example: "While the medication helped with my symptoms, it also came with a shitty side effect of constant fatigue."
Alternatives: "an unpleasant side effect" or "a negative side effect".
Exact(1)
It's a shitty side effect".
Similar(59)
A side effect of a medication(s).
It is a dangerous side effect.
A common side effect is headache.
Cabazitaxel did have a serious side effect.
"It's a nice side effect".
"It's a fortunate side effect.
"That's a good side effect".
Getting fit is a happy side effect.
A nice side effect for its business?
A common side effect is memory loss.
More suggestions(2)
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com