In this study, we describe a liposome-based siRNA delivery system with a core composed of siRNA:protamine complex and a shell designed for the active targeting of CD44-expressing cells using for the first time the anti-CD44 aptamer (named Apt1) as targeting ligand.
During the European Middle Ages the shell design of the pilgrim's scallop (Pecten jacobaeus) became a religious emblem (the badge of St. James).
For reactions of negative order, such as MGP oxidation, at high bulk oxygen concentrations (CO2,L>0.3 mol/m3), concentrating the active catalytic material in a layer buried some distance from the surface (core) gives considerable better performance than the conventional "egg shell" design of shallow deposition near the surface or uniform distribution.
Particular emphasis is given to the modelling of the relationship analyte/internal standard and the estimation of the optimal amount of internal standard to be used throughout the analytical concentration range by using a uniform shell design with a minimum number of seven experiments.
The company was so proud of an olive dish with a handle shaped like a snail's shell, designed by John Dreves of its staff, that it held a prominent spot in the futuristic Steuben pavilion at the New York World's Fair in 1939.
From the analyses and comparisons of different configurations for the stabilizing shell, a suitable shell design is chosen consisting of three sections: one primary shell, two poloidal shield shells, and two toroidal shield shells.
Given that the plant will probably be constructed in phases, perhaps inside a structural shell designed to handle the full amount of equipment, how much of the cost should Silverstein pay?
Their water filter has two components: a ceramic outer shell designed to shut out 99.9999% of bacteria and coconut-based carbon specially modified to also reduce lead in drinking water.
The shell side design of a shell-and-tube heat exchanger; in particular the baffle spacing, baffle cut and shell diameter dependencies of the heat transfer coefficient and the pressure drop are investigated by numerically modeling a small heat exchanger.
Fundamental elements of isogeometric shell design are introduced.
Relying entirely on physical test results also effectively prohibits exploration and optimisation of the shell design.
