Sentence examples for a sharp induction of from inspiring English sources
The early phase was NFAT5-independent and characterized by a sharp induction of p53 and other genotoxic stress markers (p21, GADD45α and β), downregulation of cyclins mRNA, and acute cell cycle arrest in S and G2/M.
As shown in Fig. 4C, IGF-2 mRNA levels were significantly higher in differentiated than in undifferentiated cells; thus brown adipocyte differentiation is accompanied by a sharp induction of IGF-2 expression.
Consistent with this prediction, transfection of miR203 into IMECs resulted in a sharp induction of E-cadherin and a corresponding decrease in vimentin demonstrating that miR203 opposes EMT and promotes MET.
The role of inflammation in AD is supported by a sharp induction of inflammatory mediators in AD-affected brain [ 25] as well as by epidemiological and experimental studies demonstrating that non-steroidal anti-inflammatory drugs markedly reduce the age-related prevalence of AD [ 7, 17].
The greatest developmental regulation was seen in the pathways of lipid and cholesterol metabolism and PPAR signalling; a sharp induction at SGM was shown by a suite of apolipoproteins.
In addition, we observed that an SCG pulse as short as 2.5 minutes allows 80% of the cells to enter anaphase, with similar timing (data not shown), showing very sharp induction of anaphase.
The sharp induction of complement C3, also noted in both CP compartments of MOG-CFA/PTX mice at the later time point (day 15 p.i), further supports previous studies highlighting C3 deficiency inhibits development of EAE [ 74].
IFN-α-treated Huh7 cells demonstrate a short induction of STAT1 phosphorylation (30 min–4 h), followed by a sharp reduction in ISG expression, temporally associated with the induction of the anti-inflammatory ISG USP18 (ubiquitin carboxy-terminal hydrolase 18).
Microarray studies using a developmental series from young fruits identified a sharp and transient induction of phenylpropanoid, lignin and flavonoid pathway genes concurrent with lignification and subsequent stone hardening.
There is a sharp intake of breath.
This is a sharp change of attitude.
