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The phrase "a sharp difference in" is correct and usable in written English.
It can be used to describe a significant or noticeable distinction between two or more things.
Example: "There is a sharp difference in the quality of service between the two hotels."
Alternatives: "a stark contrast in" or "a significant disparity in".
Exact(23)
But there is a sharp difference in the situations.
Warthen analyzed videotape of Green and noticed a sharp difference in his form.
The employment situation this year has been confused by a sharp difference in the two surveys the government releases each month.
A recent New York Times/CBS News poll found a sharp difference in the way men and women say they are going to vote in November.
Indeed, the poll finds a sharp difference in views of the Republican Party between Republicans who support the Tea Party movement and those who don't.
"Linking the Chinese pollution data to mortality statistics from 1991 to 2000, the researchers found a sharp difference in mortality rates on either side of the border formed by the Huai River.
Similar(37)
There was a sharp difference, however, in attitudes toward diversity.
There was a sharp difference between changes in rainfalls in 1931 1960 and 1961 1990 periods.
Many states have a sharp difference between Senators in terms of responsiveness, etc.
In a sharp difference with the previous administration of Barack Obama, a Democrat, Trump has several times called climate change a hoax.
Frequent adversaries of Mr. Giuliani's said they had also noticed his unwillingness to do battle with victims' families, and said it was a sharp difference from their own experiences in dealing with him at City Hall.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com