Exact(1)
Turning to Averroes' mature view (as found in his Long Commentary on De Anima), he advances the idea not only of a shared active intellect, but of a shared material intellect, revealing, as Taylor argues, elements of al-Farabi and Themistius in his sense of the active intellect's role in enabling the human intellect to reliably abstract from the outside world.
Similar(59)
This bias leads to incorrect comparisons, for example in the situation where the variable kinase has a low total number of active compounds, of which a higher percentage is shared with the common kinase, where normalizing by the total number of active compounds against the common kinase would underestimate SAR similarity due to a lower count in shared active compounds (despite a high percentage).
Despite this improvement on sequence-based classification, also the bioactivity-based classification needed further attention: for approximately 80% of all analyzed kinases, kinases classified as neighbors according to the bioactivity-based classification also show high SAR similarity (i.e. a high fraction of shared active compounds and therefore, interaction with similar inhibitors).
Human ODC is an obligate homodimer as two shared active sites are formed at the dimer interface between the N-terminal domain of one monomeric subunit and the C-terminal domain of the other [ 12– 12].
Overall, the shared active components had only a few common genes, indicating the complementary nature of these profiles (Fig. 5A).
Only 7 kinases (4% of the kinases analyzed) did not show a clear relationship between kinase bioactivity profile similarity and shared active compounds.
Married in 1969 and shared active retirement with her husband, invigorated by a love of mountain hiking.
The number of shared active compounds was normalized by the total number of active compounds in the variable kinase.
After mean centering of both variables (see Methods section for details) the resulting series are shown in Figure 5, where the percentage of shared active compounds is referred to as 'SAC score' (Shared Active Compound score) after mean centering.
For example, NEK_6 shares only one active compound with other kinases and therefore, can only have either 0% or 100% shared active compounds (before scaling) with other kinases, which introduces unreliable bioactivity relationships in the SAC score-distance plots.
For 80% of all analyzed kinases, those classified as neighbors according to the bioactivity-based classification also show high similarity in shared active compounds.
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