Exact(1)
The risks for renovascular effects in prior trials of the etoricoxib clinical development program were low with a shallow dose response and were generally similar to those found with naproxen or ibuprofen [ 16].
Similar(59)
In contrast, CYC3 demonstrated a shallow dose-dependent increase in toxicity.
"Numerical modelling of a new method for determination of shallow dose and deep dose in low let radiation fields". Radiation Protection Dosimetry 58, no. 2 (January 1 , 1995: 103-113.
Importantly, these shallow dose responses provide evidence against a non-specific mechanism of inhibition involving colloidal CLR01 aggregates, as aggregating inhibitors tend to exhibit steep dose response curves (Shoichet, 2006).
Kearfott, KJ; Han, S; Wagner, EC; Samei, E; Wang, CK, Numerical simulation of a TLD pulsed laser-heating scheme for determination of shallow dose and deep dose in low-LET radiation fields., Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine, vol 52 no.
Shallow dose is due to less penetrating radiations such as beta radiation and low energy x-rays.
In the case of ring badges, dose is only reported as shallow dose and is applied against the extremities dose limit.
The lens dose equivalent may not exceed 0.15 Sv (15 rem) and the shallow dose equivalent to skin or any extremity may not exceed 0.5 Sv (50 rem).
The cell lines we tested had IC50s to bafilomycin A that ranged from 10 nM to greater than 10 µM and we chose the moderately sensitive cell line HeLa (IC50 = 150 nM) for our experiments because its relatively shallow dose response made for more uniform growth inhibition experiments, suggesting that the gene expression experiments would also be more reproducible.
Shallow doses are applied against the skin dose limit.
This relatively shallow dose-response relationship between input virus dose and ensuing vector-specific NAb titers suggests that these NAb responses are fully generated by relatively low amounts (containing ≤104 PFU) of input viral inocula.
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