It probably results from a direct severing action of ET on subsets of neurons (our study), and indirect damage resulting from vasogenic edemas [4].
Villin is not the only ABP with a severing activity expressed in the IECs.
Presumably, this result is due to the severing action of sAB-4 that would disassemble F-actin nuclei immediately upon polymerization, although sAB-4 may also sequester the G-actin monomers to block polymerization.
In vitro studies have implicated Tms in the stabilization of the actin cytoskeleton by protecting actin filaments from the severing action of gelsolin [ 29] and the depolymerising action of ADF/cofilin [ 3].
Though the precise function of non-muscle tropomyosin is less understood, some in vitro studies have shown that non-muscle tropomyosins are able to differentially protect actin from the severing action of gelsolin [ 31] and can regulate the Mg-ATPase activity of myosins to varying degrees [ 32].
Tropomyosin has long been known to protect actin filaments from the depolymerizing and severing actions of DNaseI [14], ADF/cofilin [15], [16] and gelsolin [17].
The HMW isoforms Tm1 and Tm2 increase the stability of actin stress fibres [ 59] and partially protect actin filaments from the severing actions of gelsolin [ 60, 61].
We design a simple model aiming at the description of internal molecular turnover in a single podosome: actin filaments form a brush which grows from the cellular membrane whereas their size is regulated by the action of a severing agent, the gelsolin.
The new president invited the Dalai Lama to visit Czechoslovakia, thereby risking a severing of relations with Beijing.
Spastin is a microtubule severing protein whose activity is exerted preferentially on stable microtubules (Riano et al., 2009).
He was a posh, hip Tony Montana, riding around on a fixie, severing rivals' waxed moustaches with a chainsaw.
