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But sex-determining genes pose a severe problem for the organization of a genome.
But if bond yields rise a lot, that is a severe problem for a government with debt of more than 200% of GDP.
The herd, believed to be descended from a tiny transplant community brought down from Wyoming during World War I, has become a major tourist attraction — and a severe problem for park managers.
The Rover investment -- and the difficulties in getting out of it -- posed such a severe problem for BMW that some questioned its own future as an independent producer of luxury cars.
The water problem – partly the result of years of below-average rainfall – represents a severe problem for the resort's assistant manager, Marsha Stevers, who runs walking tours of Dirty Dancing locations.
Bruce Biewald, the founder and chief executive of Synapse Energy Economics, a consulting firm, said that low electricity prices were a severe problem for generators in places like the Midwest, where power is sold at auction.
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The outbreak of the Spanish Civil War in July 1936 posed a severe problem of conscience for Blum's Popular Front government: whether to send aid to the Spanish republic, the only other Popular Front regime in Europe.
For example, the maximum likelihood and other covariance-based classifiers require, on the minimum, as many training samples per class as the number of bands plus one, which creates a severe problem of field sampling for AVIRIS 224-channel data with many classes.
This finding leads to a severe problem, at least for multivariate prediction settings with several continuous covariates: For every combination of covariates only one response observation will be available under almost any practical circumstances.
In particular, we study if state dependence is a more severe problem for immigrants than for natives, which is a novel question in the literature on overeducation of immigrants.
While cross-talk between attenuation and activity is a severe problem when applying MLAA for patient attenuation estimation [15], it is not relevant for xMLAA-based hardware estimation as presented in this work.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com