The phrase "a severe model of" is correct and usable in written English.
It can be used when describing a model that is strict, harsh, or rigorous in its characteristics or requirements.
Example: "The researchers developed a severe model of climate change to predict the worst-case scenarios for future environmental impacts."
Alternatives: "a strict model of" or "a rigorous model of".
More broadly, we reported strong attenuation of clinical and biological manifestations of multi-organ failure after aortic cross-clamping in a severe model of multi-organ ischemia reperfusion mimicking low perfusion states.
With the objective of translation to clinics we have chosen a paradigm of delayed grafting, i.e., one week after lesion, in a severe model of spinal cord compression in adult rats.
With the aim of translation to the clinic, we explored the transplantation potential of hENPs either naïve, or engineered to express Ngn2 in a severe model of spinal cord compression in adult rats.
To create both a moderate and a severe model of chronic myocardial infarction that resemble these different patient groups, ischemia can be induced in several ways.
For instance, in a severe model of type 1 diabetes, Xu et al. [ 44] described that autophagy is reduced in the diabetic heart.
We used intrapulmonary administration of nebulized LPS which, together with the application of high tidal volume ventilation, created a severe model of acute lung injury with a decrease in PaO2/FiO2 ratio.
On this topic, Zhou et al. reported a beneficial effect of PL in a less severe model of sepsis in awake rats.
A study of longer duration or conducted in a less severe model of metabolic dysfunction may reveal similar effects by PF-879, however, they do not account for the positive metabolic changes observed here.
Such studies using a less severe model of CHF with better long-term survival are planned.
We also studied the role of NRG1 in a more severe model of nerve injury: sciatic nerve transection and reanastamosis (Supplementary Fig. 1B).
The authors speculated that SLV388 should be tested in a less severe model of liver injury, as very severe intoxication might not be relevantly amenable to pharmacological interventions (Hocher et al., 2011).
