The phrase "a severe model" is correct and usable in written English.
It can be used in contexts where you are describing a model that is strict, harsh, or rigorous in its parameters or outcomes.
Example: "The researchers developed a severe model to predict the worst-case scenarios of climate change impacts."
Alternatives: "a strict model" or "a harsh model."
More broadly, we reported strong attenuation of clinical and biological manifestations of multi-organ failure after aortic cross-clamping in a severe model of multi-organ ischemia reperfusion mimicking low perfusion states.
With the objective of translation to clinics we have chosen a paradigm of delayed grafting, i.e., one week after lesion, in a severe model of spinal cord compression in adult rats.
With the aim of translation to the clinic, we explored the transplantation potential of hENPs either naïve, or engineered to express Ngn2 in a severe model of spinal cord compression in adult rats.
Moreover, the surgical procedure of intestinal I/R described here is a severe model.
To create both a moderate and a severe model of chronic myocardial infarction that resemble these different patient groups, ischemia can be induced in several ways.
For instance, in a severe model of type 1 diabetes, Xu et al. [ 44] described that autophagy is reduced in the diabetic heart.
The lack of SVZ activation in our study could be due to the fact that the Batista study was examining R6/2 animals [5], which represent a more severe model, bearing a closer resemblance to juvenile-onset HD.
The improved stability is likely a result of a less severe model size penalty, which indirectly alleviates the problem of multicollinearity.
Further studies are under way to evaluate the impact of lactate sodium in a less severe model (LPS 5 mg/kg), with a decreased vascular filling and in a polymicrobial model of sepsis by caecal ligature and puncture.
On this topic, Zhou et al. reported a beneficial effect of PL in a less severe model of sepsis in awake rats.
A study of longer duration or conducted in a less severe model of metabolic dysfunction may reveal similar effects by PF-879, however, they do not account for the positive metabolic changes observed here.
