Background: It is well-known that the public still have been facing on a severe issue about the inconsistency of quality and therapeutic efficacy of traditional medicines.
Infections caused by multi-resistant germs became a severe issue due to the widespread application of antibiotics[25, 26].
PV aging in particular is an unavoidable and rather severe issue of current PV panels [20].
However, what a RORI index does not consider is a degree of self-inflicted side effects of the responses themselves, e.g., the severe issue of shutting down an extremely important central control server in order to "protect" it from an adversary.
Both economies are witnessing the emergence of a fast-growing middle class, which translates into a huge potential market, but also severe issues of air pollution.
In our society we have severe issues of huge social inequalities on a global scale, and have to deal with the catastrophic consequences of climate change (take, for example, the current drought in California, one of the most severe in history), and with the resurgence of diseases that we thought we had eliminated, such as tuberculosis.
Such blocks with high indigenous population are marked by impoverishment, marginalization and exploitation and severe issues of gender discrimination, violence and denial of rights (Public Health Resource Network [PHRN] 2010).
A more severe issue in terms of (research) ethics is that of the missing "informed consent" in SMA, comprehensively dealt with in Krieger, Grubmüller et al. [36].
It is a pathogenic bacterium responsible for several issues of severe health problems, e.g., food spoilage, chronic infections, abscesses, wound infection.
If a young person needs to drop out because of a severe unsolvable issue like bullying, teen pregnancy, or a serious medical condition they should be encouraged to get a GED.
