Sentence examples for a severe involvement from inspiring English sources

It is still, however, relevant to consider the preventive performance of a stress test in these patients with a severe involvement of PAD (Fontaine stage IIb and higher), because they are considerably limited in their normal life in terms of physical burden, and so the information about the history of cardiac symptoms has a lower predictive value.

Neuropathological examination of patients with FDD shows diffuse brain atrophy with a particularly severe involvement of the cerebellum, cerebral cortex and white matter, as well as the presence of very thin and almost demyelinated cranial nerves, and widespread amyloid angiopathy in the small blood vessels and capillaries of the cerebrum, choroid plexus, cerebellum, spinal cord and retina.

While throughout all stages of the disease, some cases tend to show a more severe involvement in one area than the other, the overall pattern of cell loss appeared to be fairly balanced between all three areas.

Studies with strong selection biases propose that alpha-synucleinopathy (AS) spreads upwards and downwards in the neuraxis from the medulla, that amygdala-dominant AS is strongly associated with Alzheimer's disease (AD), and that a more severe involvement of the cerebral cortex is correlated with increasing risk of dementia.

A few studies described a somewhat greater neurone loss in the NbM compared to LC. Jellinger et al. [ 95] reported on a somewhat more severe involvement of the NbM (15 90% neuron loss), compared to LC (4 88% cell loss).

The use of a dilator for vaginal stricture in the absence of symptoms as an indicator of severe involvement was controversial.

15, 20, 30, 31 In children, there was a male predominance at 1.4 1 in two studies, with one citing boys as having more severe involvement; a third study reported girls as having more severe disease.

Most cells were involved in glycogen accumulation, with a range from mild to severe involvement (Fig. 5B).

With severe involvement, usually a longer duration of therapy may be required.

The systemic-onset JIA is observed in 4% to 17% of patients and is characterized by a severe systemic involvement (rash, fever, hepatosplenomegaly) associated with arthritis of variable severity that may evolve into an aggressive polyarticular course [ 2].

Patient 366 had a very pronounced systemic amyloidosis with severe involvement of many parts of the body including both parenchymatous and non-parenchymatous organs.