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Histone 4 is the only nucleosomal subunit present as a single copy gene and thus its down-regulation could have severe implication on the nucleosomal assembly during the P. falciparum schizont stage.
For players in this position and for their teams, it is a season with severe implications.
Generally, fractures may have severe implications: a proximal femur or vertebral fracture in an aged man is an event that often leads to permanent disability because of the small chance of recovery.
However, if the dominance deviance is actually negative (suggesting a recessive genetic effect), the choice of a dominant test can have severe implications for power, and in the presence of a large recessive genetic effect, only a genotypic test will be suitable.
And it is a disease that has severe implications on the livelihoods of farmers and overall global food security.
Such a decision could still have severe implications for transatlantic relations at a time when Trump has already faced open disagreement and anger from many of his allies there over defense spending, trade, climate change and other issues.
If women collectively decided they would rather have a non-smoking man, this could have severe implications for smoking as a masculine social norm.
Such a shift, if it takes place, would have severe implications for hopes of a consensual peace between Israelis and Palestinians, and for wider regional stability.
Even a restructuring would likely have severe implications on his 125-member staff.
"Coral reefs are sensitive to even small changes in ocean temperature and a 1C rise would have severe implications for the Great Barrier Reef and Ningaloo reef.
"With Dropbox you can access your files through the browser and this is a feature which has very severe implications on how security has to be laid out.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com