The phrase "a severe grade" is correct and usable in written English.
It can be used when discussing the intensity or seriousness of a particular grade, often in an academic context.
Example: "After reviewing the exam results, the teacher noted that a severe grade was given to those who did not meet the minimum requirements."
Alternatives: "a harsh grade" or "a strict grade".
Three patients experienced a severe grade 4 late toxicity (all grade 4 persistent neutropenia, subsequently resolved).
Very few nonagricultural workers exhibited a severe grade of airway fibrosis (frequency score > 1.4).
19, 20 Diligent monitoring and intervention can prevent neutropenia from progressing to a severe grade and reduce the risk for infection.
Approximately 10% of patients showed a severe (grade 3 4) infusion-related reaction which may be accompanied by bronchospasm, hypotension, angioedema and/or hypoxia.
All dogs had some kind of respiratory signs (Table 1): only one dog had a mild grade of respiratory signs (grade 1), 13 (26%) suffered from a moderate grade (grade 2) and 36 (72%) from a severe grade (grade 3).
A severe grade of stromal fibrosis in metastatic carcinoma to the lymph nodes had a significantly higher ratio for tumour recurrence, and an Allred score of 7 or 8 for progesterone receptors had a significantly lower hazard ratio for tumour-related death in a multivariate analysis (Table 3).
We studied AZD9773 (plus imipenem) effects in two mouse CLP models: a mild-grade model to explore the potential for AZD9773 to compromise mouse survival, and a severe-grade model to test AZD9773 efficacy.
The number of cycles where each of the 10 listed toxicities was suffered at a severe level (CTC grade 3 or above (two for alopecia)) was compared across treatments using χ tests with continuity corrections.
Most irAEs are of low-grade severity, but are part of a severity spectrum, and, as such, may progress to a more severe grade.
More than half of patients whose EE recurred after maintenance therapy was discontinued relapsed to a less severe grade of EE compared with 18% who relapsed to a more severe grade of EE (Table 3).
The collision with Keane resulted in LaFontaine's sixth diagnosed concussion, a Grade II level injury that followed on the heels of a more severe Grade III blow that knocked him unconscious and cost him the 1996-97 seaton at Buffalo.
