Eighteen subjects withdrew prematurely due to a rash AE, including one subject, receiving allopurinol, who had a severe desquamating eruption requiring parenteral corticosteroid therapy.
Cowpox with a severe, generalized eruption was diagnosed in an atopic 4-year-old girl by electron microscopy, virus isolation, polymerase chain reaction, and immunoglobulin (Ig) M and low-avidity IgG antibodies.
The effects of such severe eruptions can be seen over a large territory, even at global scale and environmental changes arising as their result are observed not only for a single growing season but also for a few years after the event (Scuderi, 1990).
Although some degree of acneiform rash occurs in most patients, severe eruptions resulting in significant pain, pruritus, or infectious sequelae are rare.
We conclude that imatinib acts as a dose-dependent inducer of cutaneous adverse reactions with mainly mild reactivity to low or intermediate doses (200 600 mg day−1) but severe eruptions to high doses (600 1000 mg day−1) of the drug.
The low Ne estimate for Marchena, calculated over an interval in which a severe El Niño event and a volcanic eruption occurred, suggests that it is important to consider the potential synergistic relationship between El Niño and other phenomena.
He said the world would end in 1997, preceded by a number of disasters, including a severe hurricane around the Gulf of Mexico and New Orleans, eruptions in Cuba, disruption in China, a hurricane in Derry, and an earthquake on the Isle of Arran.
On the day of the eruption, several evacuation attempts were made, but a severe storm restricted communications.
Explosive eruptions from Mount Garibaldi would pose a severe threat to the nearby communities of Whistler and Squamish.
Ash from volcanoes reflects light back into space, and major eruptions in the past have had a severe, albeit temporary, cooling effect.
