Sentence examples for a severe effect in from inspiring English sources

The mutation is supposed to have a severe effect in view of site-directed mutagenesis experiments and phenotypes of some patients.

We found that mutation of serine 98 in the PAR region of Adr1, which is crucial for optimal binding [15], [16], [20], [30], had a severe effect on in vivo binding to, and activation of the ADH2 promoter.

They also survived low-pass filtering (I) and resampling, due to the fact that these two attacks do not have a severe effect on coefficients in the second-level approximation subband.

A previous study also showed a more severe effect in the methylation of the promoter and I3 regions of the Oct-4 gene in the absence of Dnmt3a than Dnmt3b [29].

Both hFXNG130V and hFXNI154F clones showed a significant decrease in the mitochondrial succinate dehydrogenase (SDH) activity with a more severe effect in the hFXNI154F mutants compared to the hFXNG130V mutants with 36% and 54% residual SDH activity, respectively (Fig. 5A).

The economic sanctions have had a "very severe" effect in Pakistan, says Andrew Hess, director of the Southwest Asia Program at the Fletcher School of Law and Diplomacy.

Thereafter, fertility decline would have a severe effect leading to a decline in consumption by one third.

The bad weather has had a severe effect on Britain's travel networks in one of the year's busiest weekends for travel; many road and rail routes have been plunged into chaos.

Our previous work has also shown that Mg depletion has a severe effect on the mouse skeleton resulting in impaired bone growth, decreased osteoblast numbers, increased osteoclast numbers and stimulation of cytokine activity in bone.

The D442G acts in dominant negative manner with severe effect in heterozygous state [ 14].

Differences between groups were seen in the severity of side effects with a tendency for less severe effects in the NT group (table 4).