Martyn moved towards a period of severe doubt about the relevance of his faith in his middle years, and felt let down by the church in its social witness.
The old idea that people should be drinking litres of water a day, apart from their regular food, was put in severe doubt a year or two ago.
"Her opponents have failed to adequately address the issues she has raised, and often choose to ignore her work because — to paraphrase a phrase from elsewhere — what she has discovered are inconvenient truths that cast severe doubt on a model that they have been peddling," says Andrew Kerr, a petrologist at Cardiff University in Wales who supports Keller.
Speaking to the BBC, he expressed severe doubt that a customs union relationship would deliver on the result of the referendum.
With Europe and America in talks about a transatlantic trade deal, Azevêdo believes the future of the WTO as a multilateral negotiating forum will be in severe doubt unless it can pick what one source called the "low hanging fruit" from the tortuous Doha process.
Mortality among those receiving bolus fluids was higher than those receiving maintenance fluids but the data are compatible with an effect ranging from a small potential benefit of bolus to very substantial harm, which raises severe doubt about the use of boluses even in this more severely ill group.
As MSPs in Edinburgh voted to enact the bill legally establishing next September's referendum, the cross-party Scottish affairs committee at Westminster said that the white paper's credibility would be thrown into severe doubt if it failed to give voters an accurate picture.
From his pulpit on Sunday, Father Scahill, a vociferous and frequent critic of the church's handling of the sexual abuse crisis, delivered a scathing sermon in which he said, "There surely is solid ground here for severe doubt" about what the Vatican says it knew about the sexual abuse.
Forensic investigation cast severe doubt on the authenticity of the documents.
The Faroese in particular believe the over-quota prosecutions puts the Scottish industry's credibility in severe doubt.
