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The phrase "a severe disease" is correct and usable in written English.
It can be used when describing a medical condition that is serious or has significant health implications.
Example: "The patient was diagnosed with a severe disease that required immediate treatment."
Alternatives: "a serious illness" or "a critical condition."
Exact(60)
Ebola hemorrhagic fever (EHF) is a severe disease caused by several species of Ebolavirus (EBOV), in the family Filoviridae.
That's already a severe disease by itself.
Schizophrenia is a severe disease that is almost always diagnosed when patients are in their teens or 20s.
This is not the first time a highly innovative approach to a severe disease has caused catastrophe.
Conclusion Cirrhosis is a severe disease.
Introduction Infective endocarditis (IE) is a severe disease, associated with a high mortality.
A majority of subjects (n=93, 83.0%) felt that oral cancer is a severe disease.
Acute pancreatitis is a severe disease with unpredictable course and outcomes.
Schizophrenia is a severe disease which affects different aspects of behavior, including cognitive functions.
Conclusion The ITE in ICU is a severe disease with frequent complications and in hospital mortality reaches 30%.
At that time, the patient experienced important emotional distress due to a severe disease suffered by her mother.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com