The phrase "a severe course of" is correct and usable in written English.
It can be used when referring to a strict or intense regimen, often in the context of treatment or discipline.
Example: "The doctor recommended a severe course of antibiotics to combat the infection."
Alternatives: "a rigorous regimen of" or "an intense treatment of".
Opel, N. et al. Obesity and major depression: Body-mass index (BMI) is associated with a severe course of disease and specific neurostructural alterations.
Given the choice between jail and a severe course of hormone treatment (known as chemical castration), he took the latter, though not for long; he killed himself two years later.
Out of 346 patients 152 (44%) had a mean co-medication period of 22.4 out of 52 weeks (see Table 2), which indicates that patients with a severe course of illness were unlikely to have been overrepresented.
Interestingly, in mice lacking the IL-1R, a severe course of TB was associated with high lung production of IL-1β, IL-6, and TNF-α [32], findings which corresponds well to the result of our study.
P. aeruginosa strains were isolated at the onset of infection and after years of chronic colonization from a CF patient with a severe course of the airways infection [8].
In addition, the role of oxidative stress has been evaluated in experimental models of acute pancreatitis [43] and it should be emphasized that oxidative stress and excessive ROS generation are early features in AP and consequently a difficult target for clinical prophylaxis to prevent a severe course of the disease.
A severe course of CAP was observed in 105 (10.5%) patients.
The identification rate was higher patients with a severe course of pneumonia.
Leukocyte count was elevated in patients with a severe course of renal failure but was not predictive at first examination.
In patients with a severe course of pneumonia, we found significantly increased IL-6 and LBP concentrations.
Namely, patients with a total score of 12 or more were defined as having a severe course of the disease.
