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The phrase "a severe course" is correct and usable in written English.
It can be used to describe a strict or intense path, often in the context of treatment, education, or a set of actions.
Example: "The doctor recommended a severe course of antibiotics to combat the infection effectively."
Alternatives: "a strict regimen" or "an intense program".
Exact(60)
It may run a severe course and become life-threatening; in mild cases, the eruption is prone to recur.
Opel, N. et al. Obesity and major depression: Body-mass index (BMI) is associated with a severe course of disease and specific neurostructural alterations.
Symptomatically, the disease ranges from a mild attack to a severe course that commences suddenly and ends in death caused by dehydration and poisoning by bacterial toxins.
Given the choice between jail and a severe course of hormone treatment (known as chemical castration), he took the latter, though not for long; he killed himself two years later.
"On an individual level it is relatively low risk, but the proportion of people who have a severe course appears to be quite high," said Rob Breiman, a respiratory expert who has worked for the World Health Organization on the outbreak.
Out of 346 patients 152 (44%) had a mean co-medication period of 22.4 out of 52 weeks (see Table 2), which indicates that patients with a severe course of illness were unlikely to have been overrepresented.
Interestingly, in mice lacking the IL-1R, a severe course of TB was associated with high lung production of IL-1β, IL-6, and TNF-α [32], findings which corresponds well to the result of our study.
P. aeruginosa strains were isolated at the onset of infection and after years of chronic colonization from a CF patient with a severe course of the airways infection [8].
In addition, the role of oxidative stress has been evaluated in experimental models of acute pancreatitis [43] and it should be emphasized that oxidative stress and excessive ROS generation are early features in AP and consequently a difficult target for clinical prophylaxis to prevent a severe course of the disease.
A severe course of CAP was observed in 105 (10.5%) patients.
One patient had a severe course, which led to renal failure secondary to amyloidosis.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com