The phrase "a severe clinical problem" is correct and usable in written English.
It can be used in medical or healthcare contexts to describe a significant issue affecting patients or treatment.
Example: "The research highlighted a severe clinical problem that requires immediate attention from healthcare professionals."
Alternatives: "a serious medical issue" or "a critical health concern."
Unstable lesions of the cervicothoracic junction present a severe clinical problem for diagnosis, treatment, and prognosis.
Major depressive disorder is a severe clinical problem across the globe, with a lifetime risk of 10%30%% for women and 7%–15% for men.
The presence of vascular calcification is a severe clinical problem, and is prognostic for an increased risk of adverse cardiovascular outcomes [1].
TRANSLATIONAL IMPACT Clinical issue Renal fibrosis is a severe clinical problem and is the most common pathogenetic cause of chronic kidney disease (CKD).
Resistance to chemo- or radiotherapy, which is often associated with recurrence after prior androgen deprivation therapy in human prostate cancer, remains a severe clinical problem [ 55].
Loco-regional relapsing is the most severe clinical problem encountered in these tumours, while the pre-operative presence of lymphnodal infiltration is a recognized prognostic factor [ 4, 5].
Cancer pain is a severe clinical health problem for these patients and currently the treatment for this pain is inadequate enhancing this problem [ 6].
On the contrary, rCAP affecting multiple lobes or different areas of the same lobe may be associated with a wide range of more or less severe clinical problems that could per se increase the risk of lung infection.
Assuming that the ED remains a primary point of service contact for this large group of older individuals with severe clinical problems, the demand placed on staff and resources will become substantial as the aging population grows in the coming decade [ 4].
Cartilage and bone defects represent common and severe clinical problems.
Early development of obesity increases the risk of adult obesity, which is associated with the emergence of very severe clinical problems.
