Sentence examples for a severe block of from inspiring English sources

XLA is a primary immunodeficiency disease caused by a severe block of B cell development at the pre-B to immature B cell stage that is induced by mutations of the human Bruton's tyrosine kinase (BTK) gene [ 2].

Somewhat analogously, deletion of VEGF-C results in a severe block in the development of the lymphatic system.

The hallmark of all AML types is a severe block in myeloid differentiation.

Unexpectedly, osteoclast differentiation and function of Nasu-Hakola patient-derived mononuclear myeloid precursors is impaired in vitro, similar to the severe block of osteoclast differentiation observed when bone or spleen myeloid precursors from Dap12-deficient mice are cultured in the presence of M-CSF and RANKL.

The accumulation of both nonlabeled and [C]PRPP denotes a severe metabolic block downstream of PRPP biosynthesis, which is consistent with the inhibition of C incorporation into downstream purine nucleotides just described.

It takes a moment to get over the shock of its Soviet-style regimentation, where the identical rooms are located in severe blocks (shades of Prisoner Cell Block H) on municipal staircases, where every room has its own democratically identical balcony overlooking the yachts in the bay and most meals are help-yourself-comrade buffets.

The main obvious functional changes that occur with the progression of CML are the severe block in differentiation, apoptosis and acceleration in proliferation.

The Akt1Akt2 thymocytes manifest a severe developmental block at the DN3 stage and ultimately fail to repopulate the T cell compartment of an irradiated host.

A struggling poet, Chowder is suffering from a severe case of writer's block.

He began, almost by default, back in 1980, with a severe case of writer's block.

Working on a musical inspired by his childhood helped the musician, who has won 16 Grammys and sold 100 million albums, overcome a severe case of writer's block.