Sentence examples for a severe block from inspiring English sources

Although intracellular growth was not primarily affected (Supplementary Fig. 1b), a severe block in host cell invasion down to 10% that of the control strain was observed (Fig. 1e).

However, as with many men diagnosed with DAZ gene deletions, DAZL-deficient rats were sterile due to a severe block in spermatogenesis [17].

These mutant mice displayed a severe block in B cell development at the differentiation from, so called, T1 to T2 B cells in the spleen, whereas the development of B-1 B cells appeared to be unaffected.

While mice lacking individual Vav family proteins show partial to no defects in T lymphocytes, VavNULL mice show a severe block in T cell development [29], [38], [39], [40], [55].

In a similar knockout mouse strain of survivin gene (lck-Cre/survivinfl/fl), for example, loss of survivin at this stage leads to a severe block in the DN to DP transition and more than 10-fold drop of the number of thymocytes [17], [18].

The hallmark of all AML types is a severe block in myeloid differentiation.

Interestingly, mast cells deficient in both RasGRP1 and RasGRP4 had a much more severe block in FcεRI-mediated signaling and mast cell function.

The Akt1Akt2 thymocytes manifest a severe developmental block at the DN3 stage and ultimately fail to repopulate the T cell compartment of an irradiated host.

S1P is recognized by S1P receptor-1 (S1P1) expressed on lymphocytes, and deficiency in S1P1 results in a severe egress block from the thymus and lymph nodes [6].

Unlike other PRC2-deficient embryonic stem cells (ESCs), however, Jarid2-deficient ESCs show a severe differentiation block, altered colony morphology, and distinctive patterns of deregulated gene expression.

The accumulation of both nonlabeled and [C]PRPP denotes a severe metabolic block downstream of PRPP biosynthesis, which is consistent with the inhibition of C incorporation into downstream purine nucleotides just described.