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The phrase "a setting of underlying" is not correct and lacks clarity in written English.
It may be intended to describe a context or framework that supports something else, but it needs additional context to be meaningful.
Example: "The study provides a setting of underlying principles that guide the research methodology."
Alternatives: "a framework of foundational" or "a context of basic".
Exact(1)
For cases in which no tissue was available, patients were diagnosed with HCC if dynamic imaging findings (CT with intravenous contrast or MRI only) of a hypervascular solid liver mass with features characteristic for HCC were present in a setting of underlying risk factors, along with a clearly elevated serum alpha-fetoprotein (>100 ng/ml).
Similar(59)
There are a set of underlying relationships, underlying balance of power, leverage on different sides, and you have to recognize when you are in a position to then on top of that find a solution given the underlying balance...
Phonemes may be further analyzed in terms of a set of underlying distinctive features, features specifying the ways the sound is physically produced by passing breath through the throat and positioning the tongue and lips.
It's sometimes possible to group seemingly diverse problems together, determine a set of underlying causes, and then learn about those causes Once they are understood, solving the individual problems is often straightforward.
Until recently, most physicists took it on faith that as they refined their theories and upgraded their experiments they would eventually expose a set of underlying rules requiring the universe to be this way and this way only.
Each of these three variables reflects a set of underlying accessible beliefs, which include behaviour beliefs, normative beliefs, and control beliefs for perceived behaviour control [ 14].
9 It includes deaths classified by a set of underlying causes within specific age groups (see supplementary appendix 1 on bmj.com).
The graph has no self-edges, i.e. Each edge in is associated with a set of underlying findings obtained from the literature, where each finding is associated with a 'sign' that represents the regulation direction of the causal effect.
FBA employs a linear programming (LP) strategy to generate a flux distribution that is optimized toward a particular 'objective', normally maximal cell growth, subject to a set of underlying physicochemical and thermodynamic constraints fitting experimental data on changes at nutritional and metabolic levels [ 43].
The toolkit includes: (1) convenient functions for genome importing and formatting, (2) modular analysis scripts that can be linked by piping to quickly and flexibly create workflows, (3) several convenient wrapper scripts that link other functions together to perform common analysis and visualization, and (4) a set of underlying Python libraries for programmatic data access.
In the setting of underlying lung disease, there is a risk factor for invasive aspergillosis at much lower doses and shorter courses of steroids [ 41, 42].
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com