The phrase "a setting of highly" is not correct and seems incomplete in written English.
It could be used in contexts discussing a specific environment or context that is characterized by high levels of something, but it requires additional information to be clear.
Example: "The novel creates a setting of highly charged emotions that captivates the reader."
Alternatives: "an environment of high" or "a context of elevated".
A recession occurs when -- according to a set of highly technical criteria -- an economic expansion stops, and begins to contract".
It proved one of several controversial juxtapositions among a set of highly contentious curatorial decisions that had chosen thematic links over chronology.
Brown's novel is based on the "discovery" of a set of highly disputed parchments called Les Dossiers Secret identifying members of a secret society, the Priory of Sion, allegedly descended from the Cathars.
The point is that this is a programme that is both a set of highly necessary and radical policies and the beginnings of thinking about how to construct a social base.
The wonderfully named security minister Admiral Lord West of Spithead as a naval captain on the staff under Mrs Thatcher's government managed to lose a set of highly classified documents about naval cuts for which he was court-martialled.
Another urges TfL to publish in advance of the next mayoral election "a set of highly transparent, basic fare income data and assumptions on which candidates can base manifesto commitments and inform the public's understanding of any proposed changes".
If we simply assume methodological nationalism, the opposite of methodological Lennonism, it seems that we will have smuggled in a set of highly contestable moral premises about the legitimacy and priority of national interests.
A lens, a shutter, a light-sensitive surface and, increasingly, a set of highly sophisticated algorithms.
A set of highly selective GSK3 inhibitors was synthesized by fine-tuning structural modifications (29 IC50 GSK3/CDK5 32/320 nM).
