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The phrase "a setback to him" is correct and usable in written English.
It can be used to describe a situation or event that causes difficulty or delay for someone.
Example: "The unexpected loss in the competition was a significant setback to him, affecting his confidence and future plans."
Alternatives: "a blow to him" or "a hindrance for him".
Exact(1)
Villas-Boas had expected Parker to need the operation but the news is nonetheless a setback to him, as he prepares for the first match of the season at Newcastle United on Saturday week.
Similar(59)
And that was the sort of shorthand, the way his enemies projected it and it wound up being a devastating setback to him and it hurt him, as I'm sure he acknowledges to this very day".
If that changes, the ruling will come as a setback to some directors who have invested or were planning to invest millions of dollars in films with him.
"It looks to be quite a setback to the industry".
"This is a setback to all emerging satellite businesses.
It is a setback to all minorities in the country.
That would be a setback to justice.
It's difficult to replace his production in the middle of our defense, but obviously it would be a setback not to have him on our football team".
"It's a setback for him, but sometimes you need these setbacks to really shape you as a manager.
The ruling today represents a significant setback to that strategy.
Youth unemployment is a major setback to sustainable growth.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com