This paper reports the synthesis, evaluation and 3D-QSAR analysis of a set of substituted N-phenyl-6-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxamides as antitubercular agents.
For example, a scaffold has a set of possible substituted positions (for example, in Fig. 1) for R1, R2, and R3 and may have different candidates for other positions.
A widely applicable three-dimensional QSAR pharmacophore model for antimalarial activity was developed from a set of 17 substituted antimalarial indolo[2,1-b]quinazoline-6,12-diones (tryptanthrins) that exhibited remarkable in vitro activity (below 100 ng/mL) against sensitive and multidrug-resistant Plasmodium falciparum malaria.
Knee replacement is a set of biomaterials that substitute for the weight-bearing elements of a knee joint to alleviate disability and pain.
A set of tetracyanoethylene (TCNE) substituted triphenylamine analogues (4 6) exhibiting strong intramolecular charge transfer (ICT) were designed and synthesized by the [2+2] cycloaddition retroelectrocyclization reaction of 3 (tris- 4-phenylethynyl-phenyl -amine) witris- 4-phenylethynyl-phenyl -amine
The undercarriage of the Avrocar was rudimentary with three small castoring wheels mounted on "stub" shafts; a set of skids was substituted later in testing although they were not normally fitted.
We therefore pursued the synthesis of a set of polycyclic or substituted aliphatic cyclic compounds in the carboxamide series Table 5.
The design, synthesis, mPGES-1 activity and in vivo PK of a novel set of substituted benzoxazoles are described herein.
We have identified a novel set of substituted 4-aryl-3- 3-aryl-1-oxo-2-propenyl -2(1H)-quinolinones that activates apoptosis in cancer cell lines with deregulated Myc, but show low activity in cell lines where Myc is not deregulated.
Voluntary accreditation – where landlords decide whether or not to sign up to a set of standards – is no substitute.
A set of seven novel N-substituted 2-anilinophenylacetamides were designed by pharmacophore generation and using flexible alignment module of MOE software.
