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The phrase "a set of substantial" is correct and usable in written English.
It can be used when referring to a collection or group of significant or considerable items, ideas, or factors.
Example: "The research presented a set of substantial findings that could impact future studies in the field."
Alternatives: "a collection of significant" or "a group of considerable".
Exact(1)
There's a big stretch role I've been eyeing for next year, which will involve a geographic relocation and a set of substantial changes for my social life, and I've been wondering if it's worth disrupting everything for such a big leap (and if I'm even qualified to vie for it in the first place).
Similar(59)
But even its upbeat ending takes place in a setting of substantial "defeat".
Dreams: Part Two, being heard in Britain for the first time is a set of four substantial but rather diffuse pieces, evoking echoes of Debussy, Scriabin, and Busoni, and ending with a strange little fantasy on a Woody Guthrie tune, though in this case the musical results don't quite justify the pianistic effort involved in playing them.
Parsimonious: To be administratively meaningful, only a small set of substantial clusters should be identified.
If there is a revolution to come in contemporary art, there is really only one way for it to go, which is back to a set of basic values, substantial ideas and a recommitment to visual expression.
While such developments "may take the G.O.P. down in individual elections," he writes in "Building Red America," the Republican Party "holds a set of advantages, some substantial and some marginal," that have enabled it to "eke out victory by slim margins in a majority of closely contested elections" and that will probably give it an edge in the foreseeable future.
The combined weight of a set of wood steps is substantial.
For us, there is a distinctly different feel to the examples that Dodds, Flemming, and others have used to illustrate their criteria; they seem to be looking at a set of phenomena that has substantial overlap with ours, but is not quite the same.
SGD has actively sought and obtained genome sequences for a set of strains with a substantial history of use and experimental results that will serve as reference genomes.
The general approach to a transition framework is the characterization and explanation of a set of long-run irreversible changes of substantial social, ecological, cultural, political, behavioral or health significance with enduring global generalization, which are experienced as a society is transformed from one state or structure to another.
The individual Hox clusters of gnathostomes have a length of some 100,000nt and share besides a set of homologous genes also a substantial amount of conserved non-coding DNA [ 35] that predominantly consists of transcription factor binding sites.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com