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In a second step, the algorithm defines a regulatory program (a set of regulator genes) for each cluster.
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Is there a set of regulators in Washington who would understand how Google or Facebook is put together?
For instance, systematic combinatorial screening led to the identification of a set of regulators, Ngn3, Pdx1 and MafA, which are over-expressed jointly to convert exocrine cells to β-like cell [24].
Here specifically we can consider a set of regulators consisting of inhibitors for BCL 2 protein (antiapoptosis) and enhancers for BAX's proapoptosis effect.
In the second step, this method assigns a set of regulators including miRNAs, transcription factors or signal transducers, to each tight cluster.
Self-surfaces are protected from complement damage by a set of regulators (Fig 1) that are either membrane anchored or in the fluid phase.
Direct methods directly reconstruct a network of pairwise regulatory interactions while module-based methods predict a set of regulators for modules of coexpressed genes treated as a single unit.
We compared our protocol to other methods by investigating whether lifespan extension required a set of regulators that were needed in some but not necessarily all C. elegans DR protocols in which they were examined.
Those sets are endowed with some "collective status" described by variables S g A and S g I, assuming that regulation works in a cooperative way: hence, the collective state of a set of regulators is over- (resp. under-) represented if and only if all elements in the set share the same status.
One specific module is a set of "master regulator" basic helix-loop-helix transcription factors that regulate individual consecutive steps in stomatal development.
To identify candidate regulator genes we created a set of potential regulators consisting of transcription factors and signal transducers, using the GO categories 'transcription factor activity' and 'signal transducer activity, resulting in 1104 genes.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com