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First, we investigate the optimal assignment of a set of passengers for the sake of maximizing total saved travel miles.
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Using a set of known driver fusions as positive examples and a set of passenger fusions from normal tissue as negative examples, we observe the superior performance of Pegasus in ROC space where its AUC is 0.97.
To compare the capability of the transformed FIS to that of the original FIS to identify mutations involved in cancer, we needed a set of somatic mutations involved in cancer development (positive set) and a set of passenger somatic variants (negative set); however, no gold-standard dataset exists.
Note that the parameter q controls the expected number of passenger mutations in a set of k passenger genes.
Since passenger mutations are relatively rare and k (the number of genes in a driver pathway) is relatively small, we expect that a set of k passenger genes will not have a mutation in the majority of the patients.
The learning task of the Random Forest classifier is to discriminate between known drivers and a set of random passenger missense mutations that match the mutation spectrum in a cancer type of interest.
Thus we assume that the probability 1−(1− q) k that a set of k passenger genes contains at least one mutation in a patient is less than a constant a < 1 2. Since 1−(1− q) k ≈ qk we have q ≤ a k.
A pickup truck that had left earlier returned with a new set of passengers.
Perhaps more worrisome, last summer, British newspapers reported on concerns that safety regulations were being sidestepped by pilots on some unidentified low-cost carriers to meet schedules allowing them less than a half hour to unload a set of bags and passengers, take on the new load and depart.
Experimenting with a premium tier could please investors looking for Lyft to cash in on a more diverse set of passengers.
But Regus has also come under fire for its approach to the Croton site, nestled between Route 9 and a set of freight and passenger railroad tracks on the western edge of town.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com