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The Optimal Experiment Design (OED) methodology for parameter estimation (based on the Fisher information matrix) relies on a set of nominal parameters.
In this study, assuming a set of nominal parameters in the mathematical model, first a nonlinear controller (drug administration) is designed based on the principle of dynamic inversion.
After selecting a set of nominal parameters within given interval, a nominal controller is first designed and then the parameter perturbation effects are evaluated by using sensitivity function methods.
For this impactor, a novel technique using a trajectory simulation was developed to elucidate average impact velocities, effective particle restitution behavior, and average losses per impact from a set of nominal attrition rates (loss/time).
As opposed to emulation-based approaches where the effects of sampling-and-hold and delays are ignored in the phase of controller design, we propose an approach in which the controller design is based on approximate discrete-time models constructed for a set of nominal (non-zero) sampling intervals and nominal delays while taking into account sampling-and-hold effects.
The rates of transcription are represented by the following tri-phasic functions, where g jk are kinetic-order parameters, typically less than 4. Given a stable, steady solution for a gene system with a set of nominal parameters, a relevant engineering question is how to construct a genetic oscillator.
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A design method is proposed for achieving a large margin subject to a constraint that the system has a set of prescribed nominal closed-loop poles.
The International Electrotechnical Commission defines a similar set of nominal impedances, but also has a coarser classification of low, medium and high impedance with medium being 600 Ω to 10 kΩ.
Locally optimal designs for nonlinear models require a single set of nominal values for the unknown parameters.
Later, experiments were conducted using only physiological concentrations, with a denser set of nominal concentration values - at least 18 unique concentrations calibrated between 1 to 400 md/dL.
In order to investigate the sensitivity to specific parameters in the metamaterial design and the robustness of the design, a set of variations on the nominal design are investigated.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com