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Shackleton himself would be leading the South Pole journey, which had suffered a serious setback during the winter when four of the remaining ponies died, mainly from eating volcanic sand for its salt content.
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The $550,000 fine that the Federal Communications Commission imposed on CBS for Janet Jackson's "wardrobe malfunction" during the 2004 Super Bowl was a serious setback to freedom of expression.
This was a serious setback and Alvarado camped his army in Nancintla for eight days, during which time he sent two expeditions against the attacking army.
Losing glyphosate would be a serious setback.
But last year Westhoff experienced a serious setback.
But it is a serious setback for judicial campaign reform.
The coup was a serious setback for democracy in Africa.
"But what has happened now is a serious setback".
I would submit that it is not a serious setback.
Yet failure to ratify it would be a serious setback.That, sadly, is a possibility.
"And we think that they have dealt that effort a serious setback.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com