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The phrase "a serious regression" is correct and usable in written English
It can be used to describe a significant decline or deterioration in a situation, condition, or performance. Example: "The recent data shows a serious regression in the company's sales figures compared to last year."
Exact(2)
The current form of the bill is a serious regression from earlier versions, it added.
At each stage of crisis, neoliberalism has gifted us with a serious regression to the past.
Similar(58)
But the revelations about Bo's behaviour indicate that old attitudes and practices still persist, and are perhaps even widespread, and could – under certain circumstances – provide the basis for a serious political regression.
Now we face the most serious regression of all.
Multicollinearity among the explanatory variables is a serious problem in regression analysis.
Multicollinearity among the predictor variables is a serious problem in regression analysis.
Using fewer variables should not be problematic, while using more variables would cause the risk for a serious downward bias of the regression coefficients.
In particular, the field of online any-time regression analysis seems to have experienced a serious lack of attention.
To investigate the association between adverse events and death we used Cox regression with split follow-up time at the occurrence of a serious adverse event.
According to the results of the logistic regression, each increase of 10 mg/day prednisone multiplied by 11 the risk of suffering a serious infection.
A serious doubt now.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com