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The phrase "a serious problem with" is correct and usable in written English.
It can be used when discussing an issue or difficulty that is significant or concerning in nature.
Example: "The company is facing a serious problem with its supply chain, which is affecting production."
Alternatives: "a major issue regarding" or "a significant challenge with".
Exact(60)
I have a serious problem with communications.
We have a serious problem with forced begging!
Early on, he developed a serious problem with drugs.
It is already a serious problem with Android software.
But there is a serious problem with this scheme.
"There is a serious problem with disrepair in the borough.
But I have a serious problem with academics.
"Either there's a serious problem with the G.A.O.
Extremely high frequency noise was never a serious problem with our circuit.
"We have a serious problem with hangers-on," said Patrick Bruner, 23, a protester and spokesman.
The UK already has a serious problem with people saving too little for their old age".
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com